Histamine
- role in central nervous system
- role in peripheral nervous system
- receptors and signaling
- agonists and antagonists
- role in disease
Role in Central Nervous System
Role in the Peripheral Nervous System
Receptors and Signaling
Agonists and Antagonists
Agonists
Antagonists
Role in Disease
Most common excitatory NT
amino acid
every neuron has glutamate receptors
Glutamine is converted to glutamate by glutaminase in the presynaptic cell, stored, and released.
Receptors include AMPA-R, NMDA-R, and MGluR.
NMDA receptors are blocked by magnesium during cell hyperpolarization, and allow Ca influx when the cell is depolarized.
these are thought to underly learning and memory and cell death during stroke.
Surrounding glial cells take up glutamate from the synapse, convert in back to glutamine, and return it to pre-synaptic cells.